![]() Our capabilities include but are not limited to: 1) germline variant detection, 2) somatic variant detection, 3) whole genome re-sequencing, 4) de novo genome assembly, 5) copy number variation, 6) structural variant discovery. For personalized medicine, whole genome sequence data will be an important tool to guide therapeutic intervention.Ĭreative Biolabs uses the advanced SuPrecision™ platform to support researchers all over the world with their genome sequencing needs. Whole genome sequencing has largely been used as a research tool and has been introduced to clinics. Genome sequencing is the most direct method of detecting mutations, such as single nucleotide polymorphisms and copy number variations. It can be divided into four stages: (1) preparation of clones comprising the entire genome of an organism (2) collection of DNA sequences of clones (3) generation of contig assembly and (4) database development. Genome sequencing is backed by automated DNA sequencing methods and computer software to assemble the enormous sequence data. The development of WGS, combined with the falling cost of the technology holds great promise for accelerating the delivery of genetic predictors of human diseases and related treatment. WGS represents the ultimate step in assaying human genetic variation at the base sequence level. WGS, also known as complete genome sequencing, determines the order of all the nucleotides in an individual's DNA and can determine variations in any part of the genome at a single time. ![]() ![]() Researchers have found that DNA variations outside the exons can affect gene activity and protein production and lead to genetic disorders-variations that whole exome sequencing would miss. Based on this advanced platform, we can provide the most comprehensive cancer WGS sequencing bioinformatics analysis for our global customers.įig.1 A representative Circos plot of cancer genome structure from WGS analysis, which indicates structural variants and copy number alterations in all human chromosomes (Nakagawa & Fujita 2018). Creative Biolabs has established the high-throughput SuPrecision™ platform for large-scale sequencing services. Whole genome sequencing (WGS) is a key driver for many medical research projects in cancer and complex genetic disorders. ![]()
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